Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Donepezil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 1.00 |
| ▸ | BCHE | P06276 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | FAAH | O00519 | 1/20 | 0.96 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.96 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.96 |
| ▸ | PDE5A | O76074 | 1/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.96 |
| ▸ | APP | P05067 | 1/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.96 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.96 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.96 |
| ▸ | DRD4 | P21917 | 1/20 | 0.96 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.96 |
| ▸ | MAOB | P27338 | 1/20 | 0.96 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Donepezil SCHEMBL4315806 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1123745 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL29424585 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL356844 | 0.99 | BCHE (0.98) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL3091472 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1815 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1559622 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL5060933 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL4979379 | 0.99 | BCHE (0.98) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL4256889 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA HRVATSKA D.O.O | 2009-05-28 | — | — | US | claimed |
| EP-1910291-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | Pliva-Istrazivanje I Razvoj D.D.O. (HR) | 2008-04-16 | — | — | EP | claimed |
| WO-2007015052-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA ISTRAZIVANJE I RAZVOJ D.O.O. (HR) | 2007-02-08 | — | — | WO | claimed |
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA HRVATSKA D.O.O | 2009-05-28 | — | — | US | disclosed |
| EP-1992616-A1 | Process for the preparation of donepezil and intermediate compounds thereof as well as hydrates of donepezil | Pliva Hrvastka D.O.O. (HR) | 2008-11-19 | — | — | EP | disclosed |
| EP-1910291-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | Pliva-Istrazivanje I Razvoj D.D.O. (HR) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015052-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA ISTRAZIVANJE I RAZVOJ D.O.O. (HR) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | ACHE, BCHE, WIZ | ACHE 1/4885BCHE 2/4885KDM4E 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.