Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.53 |
| ▸ | RAC1 | P63000 | 5/20 | 0.57 |
| ▸ | CDC42 | P60953 | 4/20 | 0.57 |
| ▸ | RAD52 | P43351 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | BAD | Q92934 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9766883 | 0.92 | RAC1 (0.50) | RAC1CDC42RAD52MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL4313884 | 0.85 | ALDH1A1 (0.76) | RAC1CDC42RAD52MAPTMAPK1 | |
| SCHEMBL13284428 | 0.82 | RAC1 (0.78) | RAC1CDC42RAD52MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL4261974 | 0.77 | ALDH1A1 (0.57) | RAC1CDC42RAD52MAPTMAPK1 | |
| SCHEMBL10132872 | 0.77 | RAC1 (0.63) | RAC1CDC42RAD52MAPTMAPK1 | |
| SCHEMBL13839324 | 0.77 | RAD52 (0.81) | RAC1CDC42RAD52MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL9651229 | 0.77 | ALDH1A1 (0.56) | RAC1CDC42RAD52MAPTMAPK1 | |
| Chelerythrine SCHEMBL9651282 | 0.74 | ALDH1A1 (0.75) | RAC1CDC42RAD52MAPTMAPK1 | |
| SCHEMBL13284018 | 0.73 | RAC1 (0.47) | RAC1CDC42RAD52MAPTMAPK1 | |
| SCHEMBL13284345 | 0.73 | RAC1 (0.54) | RAC1CDC42RAD52MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581926-B1 | ANIMAL FEEDSTUFF FOR GROWTH INCREASE | NEUFELD KLAUS (AT) | 1996-09-11 | — | — | EP | claimed |
| US-5324520-A | Intragingival delivery systems for treatment of periodontal disease | VIPONT PHARMACEUTICAL, INC. (US) | 1994-06-28 | — | — | US | claimed |
| EP-0396232-B1 | Oral rinse compositions | VIPONT PHARMA (US) | 1994-03-02 | — | — | EP | claimed |
| EP-0513544-A1 | Sanguinaria mouthrinse having improved anti microbial activity and stability | Colgate-Palmolive Company (US) | 1992-11-19 | — | — | EP | claimed |
| US-5133981-A | PURIFICATION OF BENZOPHENANTHRIDINE ALKALOIDS EXTRACTS FROM ALKALOID EXTRACTS | ATRIX LABORATORIES, INC. (US) | 1992-07-28 | — | — | US | claimed |
| EP-0489743-A1 | INTRAGINGIVAL DELIVERY SYSTEMS FOR TREATMENT OF PERIODONTAL DISEASE | VIPONT PHARMACEUTICAL, INC. (US) | 1992-06-17 | — | — | EP | claimed |
| EP-0480996-A1 | BENZOPHENANTHRIDINE ALKALOIDS FOR TOPICAL ACNE TREATMENT | ATRIX LABORATORIES, INC. (US) | 1992-04-22 | — | — | EP | claimed |
| WO-1992000718-A1 | INTRAGINGIVAL DELIVERY SYSTEMS FOR TREATMENT OF PERIODONTAL DISEASE | VIPONT PHARMACEUTICAL, INC. (US) | 1992-01-23 | — | — | WO | claimed |
| WO-1992000104-A1 | MUCOSAL DELIVERY SYSTEMS FOR TREATMENT OF PERIODONTAL DISEASE | ATRIX LABORATORIES, INC. (US) | 1992-01-09 | — | — | WO | claimed |
| US-5073368-A | Including a surfactant mixture of an amidobetaine and an ethylene oxide-propylene oxide copolymer | COLGATE-PALMOLIVE COMPANY (US) | 1991-12-17 | — | — | US | claimed |
| US-5066483-A | Benzophenanthridine alkaloids, buffer; stability; mouthwashes; plaque | VIPONT PHARMACEUTICAL, INC. (US) | 1991-11-19 | — | — | US | claimed |
| WO-1991007391-A1 | PURIFICATION OF BENZOPHENANTHRIDINE ALKALOIDS FROM ALKALOID EXTRACTS | ATRIX LABORATORIES, INC. (US) | 1991-05-30 | — | — | WO | claimed |
| US-5013553-A | Drug delivery devices | VIPONT PHARMACEUTICAL, INC. (US) | 1991-05-07 | — | — | US | claimed |
| WO-1991000728-A1 | BENZOPHENANTHRIDINE ALKALOIDS FOR TOPICAL ACNE TREATMENT | ATRIX LABORATORIES, INC. (US) | 1991-01-24 | — | — | WO | claimed |
| EP-0396232-A2 | Oral rinse compositions | VIPONT PHARMACEUTICAL, INC. (US) | 1990-11-07 | — | — | EP | claimed |
| EP-0297535-A2 | Drug delivery devices | VIPONT PHARMACEUTICAL, INC. (US) | 1989-01-04 | — | — | EP | claimed |
| US-4769452-A | Production of purity benzo-c-phenanthridine alkaloid salts | VIPONT LABORATORIES, INC. (US) | 1988-09-06 | — | — | US | claimed |
| US-4767861-A | Recovery of benzo-c-phenanthridine alkaloids | VIPONT LABORATORIES (US) | 1988-08-30 | — | — | US | claimed |
| US-4683133-A | PUMPING ALKALOID SALT SOLUTIONS ON GUMS | VIPONT LABORATORIES, INC. (US) | 1987-07-28 | — | — | US | claimed |
| US-4590061-A | BENZO-C-PHENANTHRIDINE ALKALOIDS | VIPONT LABORATORIES, INC. (US) | 1986-05-20 | — | — | US | claimed |