Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16334247 | 0.78 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL12048608 | 0.78 | KDM4E (0.45) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL10834448 | 0.78 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL2983304 | 0.77 | — | — | |
| SCHEMBL805428 | 0.76 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL15916963 | 0.76 | NPC1 (0.36) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL802299 | 0.74 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL12579033 | 0.73 | MEN1 (0.45) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL12579038 | 0.73 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 | |
| SCHEMBL12579144 | 0.73 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1KDM4ENPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046782-A2 | IMIDAZOLYLPYRIMIDINE DERIVATIVES FOR TREATMENT OF DISEASES RELATED TO GLYCOGEN SYNTHASE KINASE (GSK3) | Astra Zeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008002244-A2 | IMIDAZOL-PYRIMIDINE DERIVATIVES FOR TREATMENT OF DISEASES RELATED TO GLYCOGEN SYNTHASE KINASE (GSK3) | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |