Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.47 |
| ▸ | STK3 | Q13188 | 5/20 | 0.46 |
| ▸ | CDC7 | O00311 | 3/20 | 0.46 |
| ▸ | MARK3 | P27448 | 3/20 | 0.46 |
| ▸ | ROS1 | P08922 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | MELK | Q14680 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.46 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.46 |
| ▸ | STK4 | Q13043 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258091 | 0.80 | CHUK (0.47) | LRRK2STK3CDC7MARK3ROS1 | |
| SCHEMBL22609952 | 0.70 | CHUK (0.49) | LRRK2STK3CDC7MARK3ROS1 | |
| SCHEMBL25157557 | 0.69 | DYRK1A (0.39) | STK3CDC7MARK3ROS1FLT3 | |
| SCHEMBL4564978 | 0.69 | ALDH1A1 (0.53) | MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28520194 | 0.69 | CHUK (0.65) | LRRK2CDK8MAP2K1CAMK2ADYRK1A | |
| SCHEMBL13539589 | 0.69 | CHUK (0.50) | LRRK2STK3CDC7MARK3ROS1 | |
| SCHEMBL4907346 | 0.67 | ADORA2A (0.41) | ALDH1A1 | |
| SCHEMBL15882322 | 0.66 | DYRK1A (0.73) | DYRK1APDPK1NTRK1PIM1CDK2 | |
| SCHEMBL4252639 | 0.65 | LRRK2 (0.43) | LRRK2STK3CDC7MARK3ROS1 | |
| SCHEMBL15401270 | 0.65 | LRRK2 (1.00) | LRRK2STK3CDC7MARK3ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |