Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 12/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.37 |
| ▸ | STK3 | Q13188 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258084 | 0.80 | LRRK2 (0.47) | CHUKLRRK2CDC7ROS1KIT | |
| SCHEMBL4258096 | 0.76 | ADORA1 (0.51) | CHUKADORA2AADORA1 | |
| SCHEMBL22609954 | 0.70 | CHUK (0.63) | CHUKIKBKBADORA2AADORA1 | |
| SCHEMBL28520194 | 0.69 | CHUK (0.65) | CHUKLRRK2CDK8MAP2K1CAMK2A | |
| SCHEMBL4900909 | 0.68 | ADORA1 (0.40) | ADORA2AADORA1 | |
| SCHEMBL4907336 | 0.67 | ADORA2A (0.43) | ALDH1A1ADORA2AADORA1 | |
| SCHEMBL1261101 | 0.66 | ALDH1A1 (0.42) | ALDH1A1 | |
| SCHEMBL11181562 | 0.65 | DRD2 (0.40) | LRRK2ALDH1A1HTT | |
| SCHEMBL4252649 | 0.65 | CHUK (0.46) | CHUKIKBKBADORA2AADORA1 | |
| SCHEMBL11126668 | 0.64 | KMT2A (0.36) | ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |