Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 10/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD5 | P21918 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28520194 | 0.69 | CHUK (0.65) | ADORA1ADORA2ACHUK | |
| SCHEMBL4900919 | 0.68 | ADORA1 (0.47) | ADORA1ADORA2AHRH3ADORA2BADORA3 | |
| SCHEMBL22609954 | 0.68 | CHUK (0.63) | ADORA1ADORA2ACHUK | |
| SCHEMBL11075542 | 0.67 | KMT2A (0.60) | LTA4HKDM4ESMN1; SMN2 | |
| SCHEMBL7012697 | 0.66 | KDM4E (0.84) | DRD3LTA4HHRH1DRD1DRD4 | |
| SCHEMBL15284096 | 0.66 | DCPS (0.55) | — | |
| SCHEMBL11076999 | 0.66 | KMT2A (0.58) | DRD3DRD2LTA4HHRH1DRD1 | |
| SCHEMBL30150794 | 0.66 | LTA4H (0.73) | DRD3DRD2LTA4HHRH1DRD1 | |
| SCHEMBL1031593 | 0.66 | LTA4H (0.73) | DRD3DRD2LTA4HHRH1DRD1 | |
| SCHEMBL2957971 | 0.65 | ADORA1 (0.47) | ADORA1ADORA2AHRH3ADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |