Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 11/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27706035 | 0.87 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTMEN1KMT2A | |
| SCHEMBL4263131 | 0.87 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTMEN1KMT2A | |
| SCHEMBL4265094 | 0.85 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTMEN1KMT2A | |
| SCHEMBL4265100 | 0.85 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTMEN1KMT2A | |
| SCHEMBL4258585 | 0.77 | NFE2L2 (0.46) | NFE2L2ALDH1A1NAMPTMEN1KMT2A | |
| SCHEMBL4261210 | 0.77 | NAMPT (0.45) | NFE2L2NAMPTHDAC3ALOX5PTGS1 | |
| SCHEMBL4262713 | 0.75 | NFE2L2 (0.50) | NFE2L2ALDH1A1NAMPTMEN1KMT2A | |
| SCHEMBL27726712 | 0.75 | NFE2L2 (0.50) | NFE2L2ALDH1A1NAMPTMEN1KMT2A | |
| SCHEMBL4262721 | 0.75 | FLT1 (0.47) | NFE2L2NAMPTHDAC3FLT4 | |
| SCHEMBL4620011 | 0.73 | HTR2A (0.41) | ALDH1A1MEN1KMT2AKCNH2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904471-B1 | HETEROARYLETHENYL DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-10-21 | — | — | EP | disclosed |