Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 9/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265100 | 0.80 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTALOX5PTGS1 | |
| SCHEMBL4263131 | 0.80 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTNTSR1ALOX5 | |
| SCHEMBL4265094 | 0.80 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTALOX5PTGS1 | |
| SCHEMBL27706035 | 0.80 | NFE2L2 (0.47) | NFE2L2ALDH1A1NAMPTNTSR1ALOX5 | |
| SCHEMBL4258583 | 0.77 | NFE2L2 (0.45) | NFE2L2ALDH1A1NAMPTALOX5PTGS1 | |
| SCHEMBL4262721 | 0.69 | FLT1 (0.47) | NFE2L2NAMPT | |
| SCHEMBL4261210 | 0.69 | NAMPT (0.45) | NFE2L2NAMPTALOX5PTGS1PTGS2 | |
| SCHEMBL27726712 | 0.68 | NFE2L2 (0.50) | NFE2L2ALDH1A1NAMPTNTSR1MEN1 | |
| SCHEMBL4262713 | 0.68 | NFE2L2 (0.50) | NFE2L2ALDH1A1NAMPTNTSR1MEN1 | |
| SCHEMBL4375633 | 0.67 | PTGS2 (0.53) | PTGS1PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904471-B1 | HETEROARYLETHENYL DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-10-21 | — | — | EP | disclosed |