Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860801 | 0.93 | MAPT (0.59) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL1860803 | 0.93 | MAPT (0.59) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL5089442 | 0.81 | KMT2A (0.71) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL6912054 | 0.77 | KMT2A (0.66) | CYP1B1MAPTLMNAALDH1A1RAB9A | |
| SCHEMBL9102687 | 0.77 | CYP1B1 (0.64) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL21803794 | 0.77 | MAPT (0.64) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL9247555 | 0.77 | MAPT (0.64) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL775716 | 0.77 | MAPT (0.64) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL869265 | 0.77 | MAPT (0.64) | CYP1B1MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL869266 | 0.77 | MAPT (0.64) | CYP1B1MAPTLMNAALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745022-B1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | ATON PHARMA INC (US) | 2014-08-13 | — | — | EP | claimed |
| US-8227636-B2 | Histone deacetylase inhibitor prodrugs | MERCK HDAC RESEARCH, LLC (US) | 2012-07-24 | — | — | US | claimed |
| EP-1745022-B1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | ATON PHARMA INC (US) | 2014-08-13 | — | — | EP | disclosed |
| US-8227636-B2 | Histone deacetylase inhibitor prodrugs | MERCK HDAC RESEARCH, LLC (US) | 2012-07-24 | — | — | US | disclosed |
| US-20090023786-A1 | Histone Deacetylase Inhibitor Prodrugs | ALTON PHARMA, INC. (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1745022-A1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | Aton Pharma, Inc. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005097747-A1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | ATON PHARMA, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023786-A1 | Histone Deacetylase Inhibitor Prodrugs | HDAC1, HDAC5, HDAC7 | CYP1B1 2753/4885MAPT 1828/4885LMNA 3285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.