SCHEMBL4259140

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4259437	0.92	KDR (0.41)	ALDH1A1IDH2KDRBRAFNTRK1
	SCHEMBL4260680	0.89	KDR (0.52)	IDH2KDRBRAFNTRK1ABL1
	SCHEMBL4256796	0.88	ALDH1A1 (0.44)	ALDH1A1KDRMEN1KMT2ABRAF
	SCHEMBL4262308	0.88	ALDH1A1 (0.49)	ALDH1A1IDH2KDRCD38MEN1
	SCHEMBL4258706	0.87	NTRK1 (0.47)	IDH2KDRBRAFNTRK1ABL1
	SCHEMBL2333052	0.86	ALDH1A1 (0.51)	ALDH1A1IDH2KDRCD38MEN1
	SCHEMBL4252292	0.80	KDR (0.41)	ALDH1A1IDH2KDRNTRK1ABL1
	SCHEMBL2336170	0.78	RET (0.48)	ALDH1A1KDRNTRK1ABL1LCK
	SCHEMBL4259330	0.77	KDR (0.52)	IDH2KDRNTRK1ABL1LCK
	SCHEMBL4259427	0.77	ALDH1A1 (0.44)	ALDH1A1KDRNTRK1ABL1LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.