Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004378 | 0.87 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL2994039 | 0.87 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL2994037 | 0.87 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL3223845 | 0.87 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL2999529 | 0.87 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL3006578 | 0.85 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL3005531 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL3248337 | 0.82 | ALDH1A1 (0.75) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL3250065 | 0.81 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL3115427 | 0.81 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716319-B2 | Substituted heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |