Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260344 | 0.89 | KDR (0.56) | IDH2NTRK1KDREPHA3EPHB4 | |
| SCHEMBL4264162 | 0.87 | ALDH1A1 (0.49) | NTRK1KDREPHA3EPHB4CA12 | |
| SCHEMBL2331434 | 0.83 | NTRK1 (0.52) | IDH2NTRK1KDREPHA3EPHB4 | |
| SCHEMBL4258706 | 0.79 | NTRK1 (0.47) | IDH2NTRK1KDRRIPK1KIT | |
| SCHEMBL4260696 | 0.79 | NTRK1 (0.49) | IDH2NTRK1KDRRIPK1KIT | |
| SCHEMBL4259336 | 0.79 | NTRK1 (0.49) | IDH2NTRK1KDREPHA3EPHB4 | |
| SCHEMBL4253258 | 0.78 | KDR (0.62) | IDH2NTRK1KDR | |
| SCHEMBL2337959 | 0.75 | NTRK1 (0.51) | IDH2NTRK1KDRRIPK1KIT | |
| SCHEMBL28141772 | 0.75 | IDH2 (0.55) | IDH2NTRK1KDRALDH1A1 | |
| SCHEMBL2333774 | 0.75 | KDR (0.61) | IDH2NTRK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124633-A1 | N-OXIDES OF HETEROCYCLIC SUBSTITUTED BISARYLUREAS FOR TREATING KINASE-MEDIATED DISEASES | MERCK PATENT GESELLSCHAFT (DE) | 2009-05-14 | — | — | US | claimed |
| US-20090124633-A1 | N-OXIDES OF HETEROCYCLIC SUBSTITUTED BISARYLUREAS FOR TREATING KINASE-MEDIATED DISEASES | MERCK PATENT GESELLSCHAFT (DE) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124633-A1 | N-OXIDES OF HETEROCYCLIC SUBSTITUTED BISARYLUREAS FOR TREATING KINASE-MEDIATED DISEASES | ABL1, NME2, MAP3K1 | IDH2 481/4885NTRK1 828/4885KDR 993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.