Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 14/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2981785 | 0.99 | MPL (0.56) | MPLHPGDSHTR2CSPHK2SPHK1 | |
| SCHEMBL4262112 | 0.89 | HPGDS (0.53) | MPLHPGDSHTR2CSPHK2SPHK1 | |
| Bromide SCHEMBL2986402 | 0.88 | HPGDS (0.52) | MPLHPGDSHTR2CSPHK2SPHK1 | |
| SCHEMBL2986383 | 0.81 | MPL (0.52) | MPLSPHK2SPHK1 | |
| SCHEMBL3765828 | 0.80 | HPGDS (0.56) | MPLHPGDSMEN1KMT2A | |
| SCHEMBL5078157 | 0.80 | MPL (0.53) | MPLSPHK2SPHK1KDM1A | |
| SCHEMBL4261299 | 0.75 | MEN1 (0.60) | HPGDSHTR2CKDM1AMEN1KMT2A | |
| SCHEMBL10040500 | 0.75 | HPGDS (0.56) | HPGDSMEN1KMT2A | |
| Bromide SCHEMBL2982781 | 0.74 | MEN1 (0.59) | HPGDSHTR2CKDM1AMEN1KMT2A | |
| SCHEMBL27713695 | 0.74 | HPGDS (0.45) | HPGDSHTR2CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-B1 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | disclosed |
| CN-101243078-A | Thiazolyl piperidine derivatives useful as h3 receptor modulators | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |