Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 15/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259395 | 0.80 | MPL (0.57) | MPLSPHK2SPHK1KDM1A | |
| Bromide SCHEMBL2981785 | 0.79 | MPL (0.56) | MPLSPHK2SPHK1KDM1A | |
| SCHEMBL5074715 | 0.76 | KDM4E (0.48) | SPHK1 | |
| SCHEMBL5072482 | 0.73 | RAB9A (0.43) | MPL | |
| SCHEMBL5074749 | 0.71 | MAOA (0.44) | KDM1A | |
| SCHEMBL474161 | 0.70 | MPL (1.00) | MPLKDM1A | |
| SCHEMBL5072483 | 0.70 | CYP1A1 (0.54) | — | |
| SCHEMBL4262112 | 0.69 | HPGDS (0.53) | MPLSPHK2SPHK1TRPA1 | |
| SCHEMBL5074730 | 0.68 | MAPT (0.39) | — | |
| SCHEMBL16274016 | 0.68 | MPL (0.49) | MPLTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-A2 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-23 | — | — | EP | claimed |
| WO-2007020213-A2 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | claimed |
| EP-1945635-A2 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007020213-A2 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |