Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11286970 | 0.78 | TNKS2 (0.58) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL6124127 | 0.74 | KMT2A (0.52) | KDM4EALDH1A1HPGDMAPTPTGS2 | |
| SCHEMBL19386770 | 0.73 | CASP3 (0.57) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3754813 | 0.72 | CCNE1 (0.68) | KDM4EMAPTCDK2CCNE1GSK3B | |
| SCHEMBL6124233 | 0.72 | TNKS2 (0.49) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL7859229 | 0.71 | GAA (0.65) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL12591983 | 0.69 | MEN1 (0.52) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL29258995 | 0.68 | KMT2A (0.57) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL30310963 | 0.68 | KMT2A (0.57) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL6313062 | 0.68 | PTGS2 (0.62) | ALDH1A1MAPTSMN1; SMN2PTGS2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488721-B2 | Real time methylumbelliferone-based assay | MCMASTER UNIVERSITY (CA) | 2009-02-10 | — | — | US | disclosed |
| US-7488721-B2 | Real time methylumbelliferone-based assay | MCMASTER UNIVERSITY (CA) | 2009-02-10 | — | — | US | disclosed |
| US-20060008862-A1 | Real time methylumbelliferone-based assay | THE HOSPITAL FOR SICK CHILDREN | 2006-01-12 | — | — | US | disclosed |