Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3001105 | 0.89 | ALDH1A1 (0.64) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL3245591 | 0.86 | ALDH1A1 (0.64) | LMNATSHRALDH1A1HPGDNPSR1 | |
| SCHEMBL3007234 | 0.83 | ALDH1A1 (0.56) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL3000271 | 0.81 | ALDH1A1 (0.54) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL3004315 | 0.78 | ALDH1A1 (0.63) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL3002781 | 0.78 | ALDH1A1 (0.60) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL4263385 | 0.78 | ALDH1A1 (0.69) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL3004369 | 0.77 | ALDH1A1 (0.68) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL4259642 | 0.77 | ALDH1A1 (0.64) | LMNATSHRALDH1A1PKMHPGD | |
| SCHEMBL3002666 | 0.77 | ALDH1A1 (0.69) | LMNATSHRALDH1A1PKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |