Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260348 | 0.86 | LMNA (0.63) | ALDH1A1POLBHPGDHTTMEN1 | |
| SCHEMBL3001105 | 0.83 | ALDH1A1 (0.64) | ALDH1A1POLBHPGDHTTKMT2A | |
| SCHEMBL3263087 | 0.75 | ALDH1A1 (0.48) | ALDH1A1POLBHPGDHTTKMT2A | |
| SCHEMBL3007234 | 0.73 | ALDH1A1 (0.56) | ALDH1A1POLBHPGDHTTMEN1 | |
| SCHEMBL3250826 | 0.72 | ALDH1A1 (0.58) | ALDH1A1POLBHTTKMT2ALMNA | |
| SCHEMBL15455520 | 0.71 | ALDH1A1 (0.53) | ALDH1A1POLBHPGDHTTLMNA | |
| SCHEMBL4259642 | 0.71 | ALDH1A1 (0.64) | ALDH1A1POLBHPGDHTTKMT2A | |
| SCHEMBL3004347 | 0.70 | ALDH1A1 (0.63) | ALDH1A1POLBHPGDHTTKMT2A | |
| SCHEMBL3263970 | 0.68 | ALDH1A1 (0.51) | ALDH1A1POLBHPGDHTTKMT2A | |
| SCHEMBL2999694 | 0.68 | ALDH1A1 (0.59) | ALDH1A1POLBHPGDHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |