Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.50 |
| ▸ | ATM | Q13315 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL4264282 | 0.98 | KDM4E (0.50) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4258793 | 0.89 | KDM4E (0.47) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12316442 | 0.89 | KDM4E (0.47) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16335016 | 0.89 | HDAC3 (0.49) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL17746843 | 0.88 | HDAC3 (0.48) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL4260701 | 0.88 | KDM4E (0.46) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4348597 | 0.86 | KDM4E (0.68) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4352678 | 0.84 | KDM4E (0.68) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4257856 | 0.82 | KDM4E (0.76) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12316441 | 0.81 | HDAC3 (0.46) | KDM4EHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | CORBETT JEFFREY WAYNE | 2009-10-29 | — | — | US | disclosed |
| EP-2097420-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | Pfizer Products Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008065508-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | ACACA, PC, ACACB | KDM4E 1062/4885HDAC3 26/4885HDAC4 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.