Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262295 | 1.00 | MCHR1 (0.55) | MCHR1ADRA2ANPY5REPHX2LMNA | |
| SCHEMBL23124560 | 0.94 | MCHR1 (0.59) | MCHR1ADRA2ANPY5REPHX2LMNA | |
| SCHEMBL14606862 | 0.88 | MCHR1 (0.57) | MCHR1ADRA2ANPY5REPHX2TACR1 | |
| SCHEMBL27611215 | 0.87 | MCHR1 (0.54) | MCHR1ADRA2ANPY5REPHX2TACR1 | |
| SCHEMBL4258087 | 0.79 | ADRA2A (0.50) | MCHR1ADRA2ANPY5REPHX2HTT | |
| SCHEMBL4258082 | 0.79 | ADRA2A (0.50) | MCHR1ADRA2ANPY5REPHX2HTT | |
| SCHEMBL5527117 | 0.79 | MCHR1 (0.52) | MCHR1ADRA2ANPY5REPHX2 | |
| SCHEMBL4266637 | 0.76 | MCHR1 (0.60) | MCHR1ADRA2ANPY5REPHX2CYP1A2 | |
| SCHEMBL4266633 | 0.76 | MCHR1 (0.60) | MCHR1ADRA2ANPY5REPHX2CYP1A2 | |
| SCHEMBL23124616 | 0.76 | KDM4E (0.57) | MCHR1ADRA2ATSHRTDP1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | GPR119, HCRTR2, MCHR1 | MCHR1 3/4885ADRA2A 178/4885NPY5R 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.