Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964539 | 0.79 | CYP3A4 (0.56) | CYP3A4TSHRCA1CA2ALDH1A1 | |
| SCHEMBL13093045 | 0.77 | CYP3A4 (0.54) | CYP3A4TSHRCA1CA2ALDH1A1 | |
| SCHEMBL41991 | 0.77 | TTR (0.50) | CYP3A4TSHRHPGDHSD17B10TDP1 | |
| SCHEMBL9517127 | 0.76 | CYP3A4 (0.52) | CYP3A4TSHRCA1CA2ALDH1A1 | |
| SCHEMBL29393582 | 0.76 | MEN1 (0.57) | CYP3A4TSHRCA1CA2ALDH1A1 | |
| SCHEMBL77110 | 0.76 | MEN1 (0.57) | CYP3A4TSHRCA1CA2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6235400 | 0.74 | MEN1 (0.55) | CYP3A4TSHRCA1CA2ALDH1A1 | |
| SCHEMBL1702678 | 0.74 | ALDH1A1 (0.33) | CYP3A4TSHRALDH1A1CASP1MEN1 | |
| SCHEMBL12004107 | 0.74 | KMT2A (0.41) | TSHRALDH1A1HPGDRECQLMEN1 | |
| SCHEMBL15229427 | 0.74 | HSD17B10 (0.50) | CYP3A4CA1CA2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130143915-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2013-06-06 | — | — | US | disclosed |
| EP-2588105-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012000970-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143915-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | TYK2, IRAK1, IRAK2 | CYP3A4 1667/4885TSHR 730/4885CA1 4710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.