Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4262978 | 0.89 | PDGFRB (0.44) | MCHR1ADRA2AHRH1ADRA1AHRH4 | |
| SCHEMBL4262384 | 0.88 | CDK2 (0.38) | MCHR1ADRA2AHRH1ADRA1ACDK1 | |
| SCHEMBL4263812 | 0.88 | CDK2 (0.38) | MCHR1ADRA2AHRH1ADRA1ACDK1 | |
| SCHEMBL4262982 | 0.84 | MCHR1 (0.47) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| Trifluoroacetic Acid SCHEMBL4265548 | 0.82 | MCHR1 (0.52) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL4258661 | 0.82 | MCHR1 (0.46) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| SCHEMBL4258666 | 0.82 | MCHR1 (0.46) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| Trifluoroacetic Acid SCHEMBL4255671 | 0.81 | MCHR1 (0.67) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| Trifluoroacetic Acid SCHEMBL4260895 | 0.81 | MCHR1 (0.41) | MCHR1ADRA2AHRH1ADRA1AHTR2B | |
| Trifluoroacetic Acid SCHEMBL5670205 | 0.81 | MCHR1 (0.41) | MCHR1ADRA2AHRH1ADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | GPR119, HCRTR2, MCHR1 | MCHR1 3/4885ADRA2A 178/4885HRH1 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.