Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | C1S | P09871 | 1/20 | 0.34 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2969089 | 0.98 | HRH4 (0.49) | HRH4HPGDSPLATMEN1KMT2A | |
| SCHEMBL23964566 | 0.86 | MAPT (0.40) | HRH4HPGDSPLATMEN1KMT2A | |
| SCHEMBL4259249 | 0.84 | HPGDS (0.41) | HRH4HPGDSPLATMEN1KMT2A | |
| SCHEMBL27868578 | 0.82 | HPGDS (0.41) | HRH4HPGDSPLATMEN1KMT2A | |
| SCHEMBL2981775 | 0.76 | SLC18A3 (0.44) | HRH3IDO1C1S | |
| SCHEMBL27868564 | 0.74 | HPGDS (0.40) | HRH4HPGDSPLATMEN1KMT2A | |
| SCHEMBL10699236 | 0.74 | HRH4 (0.50) | HRH4HPGDSPLATMEN1KMT2A | |
| SCHEMBL22860589 | 0.74 | HRH4 (0.42) | HRH4HPGDSPLATMEN1KMT2A | |
| SCHEMBL1042507 | 0.74 | HPGDS (0.47) | HPGDSMEN1KMT2ABAZ2ANPC1 | |
| SCHEMBL5458440 | 0.74 | HPGDS (0.47) | HRH4HPGDSMEN1KMT2ABAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-B1 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | disclosed |
| CN-101243078-A | Thiazolyl piperidine derivatives useful as h3 receptor modulators | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |