Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2981775 | 0.89 | SLC18A3 (0.44) | SLC18A3OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL4262991 | 0.84 | HRH4 (0.50) | HPGDSHRH4PLATKMT2AMEN1 | |
| Bromide SCHEMBL2969089 | 0.83 | HRH4 (0.49) | HPGDSHRH4PLATKMT2AMEN1 | |
| SCHEMBL27868578 | 0.74 | HPGDS (0.41) | HPGDSHRH4PLATKMT2AMEN1 | |
| SCHEMBL23964566 | 0.74 | MAPT (0.40) | HPGDSHRH4PLATKMT2AMEN1 | |
| SCHEMBL2981893 | 0.73 | SLC18A3 (0.50) | HPGDSSLC18A3KMT2AMEN1NPC1 | |
| SCHEMBL2973505 | 0.73 | HSD11B1 (0.49) | HPGDSSLC18A3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5072486 | 0.72 | CYP2D6 (0.37) | KMT2AMEN1HRH3NPC1RAB9A | |
| SCHEMBL2976263 | 0.71 | LDHA (0.42) | SLC18A3KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL2986406 | 0.71 | AR (0.43) | HPGDSSLC18A3KMT2AMEN1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-B1 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | claimed |