Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1087115 | 0.88 | KCNJ1 (0.44) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 | |
| SCHEMBL1086535 | 0.84 | KCNJ1 (0.47) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 | |
| SCHEMBL1086474 | 0.83 | ALDH1A1 (0.44) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 | |
| SCHEMBL1086475 | 0.81 | ALDH1A1 (0.48) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 | |
| SCHEMBL4258668 | 0.80 | KCNJ1 (0.39) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 | |
| SCHEMBL1086032 | 0.79 | ALDH1A1 (0.41) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 | |
| SCHEMBL1086473 | 0.79 | MAPK1 (0.48) | KCNJ1ALDH1A1SMN1; SMN2TACR1KMT2A | |
| SCHEMBL1086511 | 0.79 | HTT (0.47) | KCNJ1ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL1086856 | 0.78 | ALDH1A1 (0.45) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 | |
| SCHEMBL1086417 | 0.78 | ALDH1A1 (0.42) | KCNJ1ALDH1A1SMN1; SMN2HPGDTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |