Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264870 | 0.81 | MAPK1 (0.38) | KCNJ1ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL4263536 | 0.80 | KCNJ1 (0.42) | KCNJ1ALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL1086535 | 0.79 | KCNJ1 (0.47) | KCNJ1ALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL1086474 | 0.78 | ALDH1A1 (0.44) | KCNJ1ALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4263596 | 0.77 | TACR2 (0.38) | KMT2ASMN1; SMN2MAPTTACR1MEN1 | |
| SCHEMBL4262148 | 0.77 | PNKP (0.39) | KCNJ1ALDH1A1KMT2ALMNATACR1 | |
| SCHEMBL1086475 | 0.76 | ALDH1A1 (0.48) | KCNJ1ALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4266286 | 0.76 | TACR2 (0.41) | KMT2ATACR1MEN1 | |
| SCHEMBL1087115 | 0.75 | KCNJ1 (0.44) | KCNJ1ALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL1086032 | 0.75 | ALDH1A1 (0.41) | KCNJ1ALDH1A1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |