SCHEMBL426369

SCHEMBL426369

Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.66
CSNK2A1 P68400 1/20 0.62
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
GAA P10253 2/20 0.61
ALDH1A1 P00352 2/20 0.61
RAB9A P51151 2/20 0.61
MAOA P21397 6/20 0.58
MAOB P27338 6/20 0.58
VCP P55072 1/20 0.58
MGAM O43451 1/20 0.57
SI P14410 1/20 0.57
PKM P14618 1/20 0.57
MGAM2 Q2M2H8 1/20 0.57
FBP1 P09467 1/20 0.57
KDM4E B2RXH2 2/20 0.57
MAPK1 P28482 1/20 0.57
HPGD P15428 1/20 0.56
HK1 P19367 1/20 0.56
HKDC1 Q2TB90 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8124240 1.00 MAPT (0.66) MAPTCSNK2A1MEN1KMT2AGAA
Hydrochloric Acid SCHEMBL8356902 0.98 MAPT (0.64) MAPTCSNK2A1MEN1KMT2AGAA
Bromide SCHEMBL8360677 0.98 MAPT (0.68) MAPTCSNK2A1MEN1KMT2AGAA
SCHEMBL29654068 0.93 MAPT (0.58) MAPTCSNK2A1MEN1KMT2AGAA
SCHEMBL25247614 0.85 CSNK2A1 (0.62) MAPTCSNK2A1MEN1KMT2AGAA
SCHEMBL1806545 0.84 CSNK2A1 (0.61) MAPTCSNK2A1MEN1KMT2AGAA
SCHEMBL30480033 0.84 CSNK2A1 (0.61) MAPTCSNK2A1MEN1KMT2AGAA
SCHEMBL7093116 0.84 CSNK2A1 (0.61) MAPTCSNK2A1MEN1KMT2AGAA
SCHEMBL30294205 0.83 CSNK2A1 (0.71) MAPTCSNK2A1MEN1KMT2AGAA
SCHEMBL7444589 0.82 CSNK2A1 (0.59) MAPTCSNK2A1MEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109456280-B 4-phenylthiazole-2-amine derivative containing urea structure and preparation method and application thereof 锦州医科大学 2020-11-10 CN claimed
CN-115466229-B Para-amidobenzenesulfonyl compound and application thereof 上海中医药大学 2025-01-24 CN disclosed
EP-3802530-B1 HETEROCYCLIC COMPOUNDS AS CLASS II PHOSPHOINOSITIDE 3-KINASE INHIBITORS FORSCHUNGSVERBUND BERLIN EV (DE) 2024-05-29 EP disclosed
CN-115466229-A P-acylamino benzenesulfonyl compound and application thereof 上海中医药大学 2022-12-13 CN disclosed
EP-3802530-A1 HETEROCYCLIC COMPOUNDS AS CLASS II PHOSPHOINOSITIDE 3-KINASE INHIBITORS Forschungsverbund Berlin E.V. (DE) 2021-04-14 EP disclosed
CN-109456280-B 4-phenylthiazole-2-amine derivative containing urea structure and preparation method and application thereof 锦州医科大学 2020-11-10 CN disclosed
CN-107501204-B Method for synthesizing 1, 3-substituted thiazole ring compound from styrene compound 河南师范大学 2020-03-06 CN disclosed
WO-2019234237-A1 HETEROCYCLIC COMPOUNDS AS CLASS II PHOSPHOINOSITIDE 3-KINASE INHIBITORS FORSCHUNGSVERBUND BERLIN E.V. (DE) 2019-12-12 WO disclosed
EP-2917190-B1 NEW BENZENE SULFONAMIDE THIAZOLE COMPOUNDS INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (INSERM) (FR) 2017-07-19 EP disclosed
US-9567310-B2 Benzene sulfonamide thiazole compounds INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHARCHE MEDICALE) (FR) 2017-02-14 US disclosed
US-5550252-A IMIDAZOLINE DYES FOR DYE DONOR ELEMENTS IN THERMAL PRINTING AGFA-GEVAERT, N. V. (BE) 1996-08-27 US disclosed
US-5489568-A Triazene dyes for use in thermal transfer printing AGFA-GEVAERT, N.V. (BE) 1996-02-06 US disclosed
WO-1996001825-A1 HETEROBICYCLIC DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-01-25 WO disclosed
US-5438122-A Triazene dyes for use in thermal transfer printing AGFA-GEVAERT, N.V. (BE) 1995-08-01 US disclosed
EP-0627325-A2 Triazene dyes for use in thermal transfer printing AGFA-GEVAERT N.V. (BE) 1994-12-07 EP disclosed
US-5356857-A Triazene dyes for use in thermal transfer printing AGFA-GEVAERT, N.V. (BE) 1994-10-18 US disclosed
EP-0540143-A2 Compounds and methods for inhibition of HIV and related viruses Medivir Aktiebolag (SE) 1993-05-05 EP disclosed
WO-1993003022-A1 COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES MEDIVIR AB (SE) 1993-02-18 WO disclosed
US-4124581-A FOR NATURAL AND SYNTHETIC FIBERS, COLORFAST BAYER AKTIENGESELLSCHAFT (DE) 1978-11-07 US disclosed
US-4006127-A Cationic diazacyanine dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed