Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25517038 | 0.79 | EPHX2 (0.42) | SMN1; SMN2 | |
| SCHEMBL28870451 | 0.76 | HTT (0.31) | LMNAHTTGAA | |
| SCHEMBL25518362 | 0.74 | ALDH1A1 (0.40) | POLBLMNAHTTKMT2A | |
| SCHEMBL18696974 | 0.72 | POLB (0.62) | POLBLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL14018620 | 0.72 | POLB (0.62) | POLBLMNASMN1; SMN2HTT | |
| SCHEMBL13752301 | 0.72 | POLB (0.62) | POLBLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL14536911 | 0.72 | POLB (0.62) | POLBLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL13629873 | 0.71 | POLB (0.60) | POLBLMNASMN1; SMN2KMT2A | |
| SCHEMBL16136078 | 0.70 | HPGD (0.53) | LMNASMN1; SMN2HTTRECQL | |
| SCHEMBL30674690 | 0.69 | HTT (0.30) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133135-A1 | SPIRO (PIPERIDINE-4, 2 ' -PYRROLIDINE) -1- (3, 5- TRIFLUOROMETHYL PHENYL) METHYLCARBOXAMIDES AS NK1 TACHIKYNIN RECEPTOR ANTAGONISTS | GLAXO WELLCOME MANUFACTURING PTE LTD (SG) | 2009-11-05 | — | — | WO | disclosed |