Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4266940 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1RECQLPOLBCYP3A4 | |
| SCHEMBL1544580 | 0.85 | — | — | |
| SCHEMBL14564699 | 0.76 | CYP3A4 (0.68) | SMN1; SMN2ALDH1A1POLBCYP3A4TP53 | |
| SCHEMBL8396968 | 0.76 | — | — | |
| SCHEMBL8395652 | 0.74 | CYP3A4 (0.73) | SMN1; SMN2ALDH1A1POLBCYP3A4TP53 | |
| SCHEMBL19705884 | 0.74 | CYP3A4 (0.73) | SMN1; SMN2ALDH1A1POLBCYP3A4TP53 | |
| SCHEMBL19705885 | 0.74 | CYP3A4 (0.73) | SMN1; SMN2ALDH1A1POLBCYP3A4TP53 | |
| SCHEMBL19705886 | 0.74 | CYP3A4 (0.73) | SMN1; SMN2ALDH1A1POLBCYP3A4TP53 | |
| SCHEMBL7928146 | 0.74 | CYP3A4 (0.73) | SMN1; SMN2ALDH1A1POLBCYP3A4TP53 | |
| SCHEMBL19705995 | 0.74 | CYP3A4 (0.73) | SMN1; SMN2ALDH1A1POLBCYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485632-B2 | Cephalosporins | NABRIVA THERAPEUTICS FORSCHUNGS GMBH (AT) | 2009-02-03 | — | — | US | disclosed |
| EP-1529050-B1 | CEPHALOSPORINS | SANDOZ AG (CH) | 2006-05-24 | — | — | EP | disclosed |
| US-20050234233-A1 | e.g. 3-{(E)[[1-trans-(4-Amino-cyclohexylamino)-iminomethyl]-methylhydrazono]methyl}-7- {[(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluoromethoxyimino)-acetyl]amino}-3-cephem-4-carboxylic acid; microbiocide; Escherichia, Enterobacter, Enterococcus, Klebsiella, Streptococcus, Staphylococcus and Pseudomonas | NABRIVA THERAPEUTICS AG (AT) | 2005-10-20 | — | — | US | disclosed |
| CN-1678616-A | Cephalosporins | SANDOZ AG (CH) | 2005-10-05 | — | — | CN | disclosed |
| EP-1529050-A1 | CEPHALOSPORINS | Sandoz AG (CH) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004007505-A1 | CEPHALOSPORINS | SANDOZ AG (CH) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234233-A1 | e.g. 3-{(E)[[1-trans-(4-Amino-cyclohexylamino)-iminomethyl]-methylhydrazono]methyl}-7- {[(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluoromethoxyimino)-acetyl]amino}-3-cephem-4-carboxylic acid; microbiocide; Escherichia, Enterobacter, Enterococcus, Klebsiella, Streptococcus, Staphylococcus and Pseudomonas | CD14, GNE, ECH1 | SMN1; SMN2 4730/4885ALDH1A1 1071/4885RECQL 4658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.