ECH1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1546680	1.00	1/20
SCHEMBL1546654	0.89	1/20
SCHEMBL1547080	0.89	1/20
SCHEMBL1555915	0.88	1/20
SCHEMBL1591147	0.87	1/20
SCHEMBL1592254	0.85	1/20
SCHEMBL1546563	0.85	1/20
SCHEMBL1546888	0.85	1/20
SCHEMBL1547378	0.84	1/20
SCHEMBL1546564	0.83	1/20
SCHEMBL1557375	0.83	1/20
SCHEMBL1546915	0.82	1/20
SCHEMBL1547098	0.81	1/20
SCHEMBL1546622	0.81	1/20
SCHEMBL1546615	0.81	1/20
SCHEMBL1546626	0.81	1/20
SCHEMBL1546623	0.80	1/20
SCHEMBL1546573	0.80	1/20
SCHEMBL1546663	0.80	1/20
SCHEMBL1555991	0.80	1/20

Clinical trials — most relevant to ECH1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis	PHASE4	RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects	PHASE2	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula	PHASE2	COMPLETED
Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer	PHASE2	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Choline Effects - Pre-symptomatic AD	PHASE1	COMPLETED
Open-Trial of EPI-743 for Adults With Tourette Syndrome	PHASE1	COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease	nan	COMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
Epidemiology of Atherosclerosis	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis	nan	UNKNOWN
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Association of SGLT2 Inhibitors Therapy With Elastographic and Molecular Markers of Liver Injury in Type 2 Diabetes	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Dietary Intake of Whole Walnuts in Adult Subjects Under Low Cardiovascular Risk	nan	COMPLETED
Ketogenic Diet Therapy for Autism Spectrum Disorder	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ECH1 binder may also engage these)

Protein	Name	Similarity
Q5RFG0	—	1.000	Q5RFG0 →
Q62651	—	0.991	Q62651 →
O35459	—	0.987	O35459 →
Q58DM8	—	0.963	Q58DM8 →
P42125	—	0.963	P42125 →
ECHS1	Enoyl-CoA hydratase, mitochondrial	0.958	landscape →
P14604	—	0.957	P14604 →
P23965	—	0.955	P23965 →
Q8BH95	—	0.954	Q8BH95 →
F1NB38	—	0.954	F1NB38 →
Q5R646	—	0.953	Q5R646 →
Q2KIL4	—	0.950	Q2KIL4 →
Q9NTX5	—	0.948	Q9NTX5 →
Q5I0K3	—	0.948	Q5I0K3 →
Q3MIE0	—	0.947	Q3MIE0 →
Q9PTM4	—	0.947	Q9PTM4 →
ECI1	Enoyl-CoA delta isomerase 1, mitochondrial	0.947	landscape →
Q5R4W0	—	0.945	Q5R4W0 →
GLS2	Glutaminase liver isoform, mitochondrial	0.945	landscape →
Q64323	—	0.945	Q64323 →
Q96DC8	—	0.945	Q96DC8 →
Q811P6	—	0.945	Q811P6 →
Q8R4N0	—	0.944	Q8R4N0 →
Q2HJD5	—	0.944	Q2HJD5 →
Q8N0X4	—	0.943	Q8N0X4 →
Q8R1S0	—	0.943	Q8R1S0 →
LDHA	L-lactate dehydrogenase A chain	0.942	landscape →
F1R6N4	—	0.942	F1R6N4 →
Q6AYG5	—	0.941	Q6AYG5 →
P84850	—	0.940	P84850 →