Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2984301 | 0.98 | HPGDS (0.60) | HPGDSMKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL2636212 | 0.91 | HPGDS (0.52) | HPGDSMKNK1MKNK2KMT2ABAZ2A | |
| SCHEMBL2297392 | 0.88 | HPGDS (0.78) | HPGDSKMT2AMEN1BAZ2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL1653092 | 0.86 | HPGDS (0.76) | HPGDSKMT2AMEN1BAZ2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3768256 | 0.86 | HPGDS (0.76) | HPGDSKMT2AMEN1BAZ2AL3MBTL1 | |
| Bromide SCHEMBL2973216 | 0.86 | HPGDS (0.76) | HPGDSKMT2AMEN1BAZ2AL3MBTL1 | |
| SCHEMBL12791652 | 0.85 | HSD11B1 (0.48) | HPGDSKMT2AHSD11B1L3MBTL1KDM4E | |
| SCHEMBL4262100 | 0.85 | HPGDS (0.59) | HPGDSKMT2AMEN1BAZ2AL3MBTL1 | |
| SCHEMBL4259512 | 0.85 | HPGDS (0.59) | HPGDSKMT2AMEN1BAZ2AL3MBTL1 | |
| SCHEMBL3772350 | 0.85 | HPGDS (0.59) | HPGDSMKNK1MKNK2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-B1 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | disclosed |
| CN-101243078-A | Thiazolyl piperidine derivatives useful as h3 receptor modulators | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |