Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.52 |
| ▸ | ABL1 | P00519 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | HCK | P08631 | 5/20 | 0.52 |
| ▸ | SRC | P12931 | 5/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.52 |
| ▸ | MTOR | P42345 | 5/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.52 |
| ▸ | PRKDC | P78527 | 5/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267729 | 0.83 | KDR (0.53) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL846923 | 0.72 | BRD4 (0.47) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL27612533 | 0.71 | PIK3CD (0.46) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL129497 | 0.71 | PIK3CD (0.83) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL4267300 | 0.70 | DYRK1A (0.45) | PIK3CAMTORTGFBR1 | |
| SCHEMBL2315798 | 0.68 | SRC (1.00) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL4269315 | 0.67 | SRC (0.52) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL14574776 | 0.66 | PIK3CD (1.00) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL23251820 | 0.65 | FYN (0.65) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL1640616 | 0.65 | BRAF (0.58) | PIK3CDABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076037-A1 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | claimed |
| WO-2008039359-A2 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-03 | — | — | WO | claimed |
| US-8314234-B2 | Bicyclic pyrimidine kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-11-20 | — | — | US | disclosed |
| US-20090076037-A1 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | disclosed |
| WO-2008039359-A2 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076037-A1 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | DCK, CDK2, DTYMK | PIK3CD 96/4885ABL1 161/4885EGFR 1356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.