Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 4/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | HCK | P08631 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.53 |
| ▸ | MTOR | P42345 | 4/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.53 |
| ▸ | PRKDC | P78527 | 4/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265699 | 0.83 | PIK3CD (0.52) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL4267300 | 0.70 | DYRK1A (0.45) | PIK3CAMTORTGFBR1DYRK1A | |
| SCHEMBL3027244 | 0.69 | MAPKAPK2 (0.59) | KDRMAPKAPK2RIPK2ROCK2GSK3B | |
| SCHEMBL4559483 | 0.69 | KDR (0.53) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL31467186 | 0.66 | ROCK2 (0.49) | KDRMAPKAPK2RIPK2ROCK2GSK3B | |
| SCHEMBL4269315 | 0.66 | SRC (0.52) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL2068939 | 0.66 | MAPKAPK2 (0.65) | MAPKAPK2ROCK2GSK3BPIM1AURKB | |
| SCHEMBL27871388 | 0.65 | GSK3B (0.42) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL4558196 | 0.65 | KDR (0.47) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL2026289 | 0.64 | RIPK2 (0.49) | KDRPIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076037-A1 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | claimed |
| WO-2008039359-A2 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-03 | — | — | WO | claimed |
| US-8314234-B2 | Bicyclic pyrimidine kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-11-20 | — | — | US | disclosed |
| US-20090076037-A1 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | disclosed |
| WO-2008039359-A2 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076037-A1 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | DCK, CDK2, DTYMK | KDR 1646/4885PIK3CD 96/4885ABL1 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.