Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 9/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.37 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | HCK | P08631 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4218178 | 0.80 | TLR7 (0.50) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4225393 | 0.79 | LDHA (0.47) | TLR7TLR9TLR8FGFR1FGFR2 | |
| SCHEMBL4219353 | 0.79 | TLR7 (0.54) | TLR7TLR9TLR8FGFR1FGFR2 | |
| SCHEMBL4215536 | 0.77 | TLR7 (0.53) | TLR7TLR9TLR8FGFR1FGFR2 | |
| SCHEMBL4220662 | 0.76 | TLR7 (0.54) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4222317 | 0.75 | TLR7 (0.47) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4045726 | 0.75 | KMT2A (0.57) | TLR7TLR9TLR8SRCKDR | |
| SCHEMBL4217093 | 0.74 | TLR7 (0.53) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4054719 | 0.74 | TLR7 (0.46) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4054519 | 0.74 | TLR7 (0.48) | TLR7TLR9TLR8PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | TLR7 1301/4885TLR9 1750/4885TLR8 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.