Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.33 |
| ▸ | MAOB | P27338 | 5/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 3/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28844972 | 0.73 | BACE1 (0.32) | BACE1 | |
| SCHEMBL5607855 | 0.73 | BACE1 (0.33) | BACE1BACE2RENAPP | |
| SCHEMBL11790546 | 0.71 | SLC6A2 (0.31) | — | |
| SCHEMBL11790550 | 0.71 | MAOA (0.35) | MAOAMAOBTAAR1DPP4 | |
| Hydrochloric Acid SCHEMBL28531913 | 0.71 | KDM1A (0.40) | MAOAMAOBKDM1A | |
| SCHEMBL28213844 | 0.68 | — | — | |
| SCHEMBL11557726 | 0.67 | — | — | |
| SCHEMBL7270073 | 0.67 | PKM (0.37) | — | |
| SCHEMBL17532797 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL28524750 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062236-A1 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-03-05 | — | — | US | disclosed |
| US-7169611-B2 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-01-30 | — | — | US | disclosed |
| EP-0758249-B1 | PROGRAMMABLE GENOTOXIC AGENTS AND USES THEREFOR | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20030220311-A1 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2003-11-27 | — | — | US | disclosed |
| US-6500669-B1 | FOR SELECTIVELY KILLING A SUBPOPULATION OF CELLS IN A HETEROGENOUS CELL POPULATION; ALKYLATING AGENTS OR HEAVY METAL COORDINATION COMPOUNDS LINKED TO A COMPOUND THAT BINDS TO STEROID RECEPTOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-12-31 | — | — | US | disclosed |
| US-5879917-A | DESIGNED TO KILL SELECTED CELLS PRESENT IN HETERGENOUS CELL POPULATION; CAUSE SELECTIVE KILLING OF TRANSFORMED CELLS, VIRAL-INFECTED CELLS, ETC. | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0758249-A1 | PROGRAMMABLE GENOTOXIC AGENTS AND USES THEREFOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030442-A1 | PROGRAMMABLE GENOTOXIC AGENTS AND USES THEREFOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1995-11-16 | — | — | WO | disclosed |