Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.41 |
| ▸ | EPOR | P19235 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | EBP | Q15125 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17707693 | 1.00 | MEN1 (0.57) | MEN1KMT2AKDM4EKCNH2IDO1 | |
| SCHEMBL2774560 | 0.83 | MEN1 (0.63) | MEN1KMT2AKDM4EKCNH2IDO1 | |
| SCHEMBL2774559 | 0.83 | MEN1 (0.63) | MEN1KMT2AKDM4EKCNH2IDO1 | |
| SCHEMBL9352733 | 0.82 | MEN1 (0.48) | MEN1KMT2AKDM4EKCNH2IDO1 | |
| SCHEMBL6974136 | 0.81 | KDM4E (0.51) | MEN1KMT2AKDM4EKCNH2HTR2A | |
| SCHEMBL6974141 | 0.81 | KDM4E (0.51) | MEN1KMT2AKDM4EKCNH2HTR2A | |
| SCHEMBL3299271 | 0.81 | MEN1 (0.62) | MEN1KMT2AKDM4EKCNH2HTR2A | |
| SCHEMBL3299266 | 0.81 | MEN1 (0.62) | MEN1KMT2AKDM4EKCNH2HTR2A | |
| Water SCHEMBL31499005 | 0.79 | MEN1 (0.60) | MEN1KMT2AKDM4EKCNH2HTR2A | |
| SCHEMBL3305918 | 0.78 | KCNH2 (0.62) | MEN1KMT2AKDM4EKCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036909-B1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | UNIV BEIJING (CN) | 2016-05-04 | — | — | EP | disclosed |
| US-9133195-B2 | Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof | PEKING UNIVERSITY (CN) | 2015-09-15 | — | — | US | disclosed |
| US-20090325929-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | PEKING UNIVERSITY (CN) | 2009-12-31 | — | — | US | disclosed |
| EP-2036909-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | Peking University (CN) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325929-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | CHRM4, CHRM1, CHRNA4 | MEN1 2868/4885KMT2A 1695/4885KDM4E 2070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.