Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | CA9 | Q16790 | 2/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | GRM5 | P41594 | 4/20 | 0.60 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132140 | 0.94 | GRM5 (0.66) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL30707880 | 0.94 | GRM5 (0.66) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL702612 | 0.90 | CA12 (0.66) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL13335288 | 0.86 | CA12 (0.62) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL28074286 | 0.85 | APP (0.52) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL4309875 | 0.85 | GRM5 (0.58) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL29994376 | 0.83 | GRM5 (0.56) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL28215433 | 0.83 | GRM5 (0.56) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL7601866 | 0.83 | GRM5 (0.56) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL27952694 | 0.82 | GRM5 (0.55) | CA12CA1CA2CA9FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016172631-A2 | SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-10-27 | — | — | WO | disclosed |
| US-8735630-B2 | Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-05-27 | — | — | US | disclosed |
| US-8735630-B2 | Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20130178632-A1 | Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-07-11 | — | — | US | disclosed |
| US-20130178632-A1 | Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-07-11 | — | — | US | disclosed |
| US-8378145-B2 | Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-02-19 | — | — | US | disclosed |
| US-8169882-B2 | High density data storage medium, method and device | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2012-05-01 | — | — | US | disclosed |
| US-7642391-B1 | Palladium-catalyzed coupling of aryl halides with alkynes | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20090287016-A1 | Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-11-19 | — | — | US | disclosed |
| US-7560596-B2 | Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-07-14 | — | — | US | disclosed |
| US-7105707-B2 | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds | PHARMACORE, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20060173186-A1 | Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-08-03 | — | — | US | disclosed |
| US-20050137402-A1 | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds | DSM N.V. (NL) | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090287016-A1 | Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions | NBAS, APEX1, CBR3 | CA12 140/4885CA1 200/4885CA2 73/4885 |
| US-20060173186-A1 | Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions | NBAS, APEX1, CBR3 | CA12 140/4885CA1 200/4885CA2 73/4885 |
| US-20130178632-A1 | Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions | NBAS, APEX1, CBR3 | CA12 140/4885CA1 200/4885CA2 73/4885 |
| US-20050137402-A1 | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds | NAT1, B3GNT2, NISCH | CA12 2445/4885CA1 3028/4885CA2 3612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.