Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 16/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003457 | 0.71 | HTR6 (0.46) | PKMPKLRHTR6 | |
| SCHEMBL1999781 | 0.69 | HTR6 (0.46) | PKMPKLRHTR6 | |
| SCHEMBL1997804 | 0.69 | HTR6 (0.43) | PKMPKLRHTR6 | |
| SCHEMBL2001693 | 0.68 | HTR6 (0.46) | PKMPKLRHTR6 | |
| Trifluoroacetic Acid SCHEMBL1993157 | 0.67 | HTR6 (0.41) | PKMPKLRHTR6PTGDRPTGDR2 | |
| SCHEMBL2001918 | 0.66 | PKM (0.44) | PKMPKLRHTR6HTTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2000044 | 0.65 | HTR6 (0.39) | PKMPKLRHTR6 | |
| Trifluoroacetic Acid SCHEMBL1998224 | 0.65 | HTR6 (0.40) | PKMPKLRHTR6 | |
| SCHEMBL1997377 | 0.65 | HTR6 (0.40) | HTR6 | |
| SCHEMBL1994607 | 0.65 | HTR6 (0.42) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091953-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4]OXAZEPINO [6, 7-E]INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (publ) (SE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054288-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (PUBL) (SE) | 2008-05-08 | — | — | WO | disclosed |