Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 19/20 | 0.58 |
| ▸ | PTPRF | P10586 | 1/20 | 0.58 |
| ▸ | PTPRA | P18433 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.58 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267766 | 1.00 | ADAMTS5 (0.61) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4262191 | 0.95 | ADAMTS5 (0.56) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4262194 | 0.95 | ADAMTS5 (0.56) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4271364 | 0.91 | ADAMTS5 (0.52) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4271368 | 0.91 | ADAMTS5 (0.52) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4261025 | 0.90 | PTPN1 (0.54) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4261026 | 0.90 | PTPN1 (0.54) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4268780 | 0.87 | PTPN1 (0.53) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4268783 | 0.87 | PTPN1 (0.53) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 | |
| SCHEMBL4267329 | 0.84 | PTPN1 (0.51) | ADAMTS5PTPN1PTPRFPTPRAPTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082392-A1 | Substituted Carboxylic Acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC | 2009-03-26 | — | — | US | claimed |
| JP-2006525329-A | — | — | 2006-11-09 | — | — | JP | claimed |
| EP-1620420-A2 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | claimed |
| US-20040266788-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-30 | — | — | US | claimed |
| WO-2004099168-A2 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | claimed |
| US-20090082392-A1 | Substituted Carboxylic Acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC | 2009-03-26 | — | — | US | disclosed |
| US-7358364-B2 | treatment of diabetes and/or cancer; useful in the treatment of syndrome X; capable of inhibiting Protein tyrosine phosphatase | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2008-04-15 | — | — | US | disclosed |
| EP-1620420-A2 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20040266788-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-30 | — | — | US | disclosed |
| WO-2004099168-A2 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266788-A1 | Substituted carboxylic acids | PTP4A1, PTPRS, G6PC1 | ADAMTS5 4269/4885PTPN1 11/4885PTPRF 8/4885 |
| US-20090082392-A1 | Substituted Carboxylic Acids | PTPRJ, PTPRS, PTPRG | ADAMTS5 3915/4885PTPN1 16/4885PTPRF 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.