Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18988227 | 0.92 | LMNA (0.41) | POLBLMNASMN1; SMN2HCRTR2GBA2 | |
| SCHEMBL14144107 | 0.83 | POLB (0.45) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL5250880 | 0.82 | POLB (0.44) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL5250883 | 0.82 | POLB (0.44) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL3982504 | 0.82 | POLB (0.53) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL1982237 | 0.82 | POLB (0.53) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL6207733 | 0.82 | POLB (0.53) | POLBLMNASMN1; SMN2GBA2L3MBTL1 | |
| SCHEMBL18497662 | 0.81 | LMNA (0.44) | LMNAL3MBTL1RAB9AALDH1A1GAA | |
| SCHEMBL1439521 | 0.81 | LMNA (0.49) | POLBLMNASMN1; SMN2GBA2RAB9A | |
| SCHEMBL7563929 | 0.81 | POLB (0.43) | POLBLMNASMN1; SMN2GBA2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |