Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.46 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264981 | 0.89 | NR3C2 (0.59) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4259481 | 0.89 | ALDH1A1 (0.55) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4264187 | 0.89 | CYP19A1 (0.53) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4264625 | 0.89 | ALDH1A1 (0.55) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4271257 | 0.88 | MAPT (0.49) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4264617 | 0.88 | CYP19A1 (0.53) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL13932202 | 0.87 | POLB (0.51) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4267890 | 0.87 | ALDH1A1 (0.53) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4260692 | 0.85 | POLB (0.52) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4269384 | 0.85 | POLB (0.52) | POLBMAPTALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-02-26 | — | — | US | claimed |
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-02-26 | — | — | US | disclosed |
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054417-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | NR5A1, ESRRA, NR3C1 | POLB 2747/4885MAPT 3273/4885ALDH1A1 3483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.