Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267501 | 0.86 | PTGDR2 (0.55) | PTGDR2ADRB3ALDH1A1MAPTPPARG | |
| SCHEMBL4271717 | 0.81 | PTGDR2 (0.41) | PTGDR2ADRB3PTGS1ADORA3ADORA2A | |
| SCHEMBL4267950 | 0.80 | PTGDR2 (0.46) | PTGDR2ADRB3PTGS1ALDH1A1FFAR1 | |
| SCHEMBL4281384 | 0.80 | PTGDR2 (0.39) | PTGDR2ADRB3ALDH1A1CYP1A2GAA | |
| SCHEMBL4272568 | 0.79 | PTGDR2 (0.41) | PTGDR2ADRB3PTGS1ADORA3ADORA2A | |
| SCHEMBL3159417 | 0.74 | PTGDR2 (0.55) | PTGDR2FABP4CYP1A2GAACYP2C9 | |
| SCHEMBL4272320 | 0.73 | PTGDR2 (0.56) | PTGDR2PPARGPPARA | |
| SCHEMBL4271985 | 0.73 | PTGDR2 (0.56) | PTGDR2PPARGPPARA | |
| SCHEMBL4276035 | 0.73 | PTGDR2 (0.41) | PTGDR2PPARGPPARA | |
| SCHEMBL3168477 | 0.72 | PTGDR2 (0.73) | PTGDR2ADRB3CYP1A2GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |