Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267953 | 0.86 | PTGDR2 (0.59) | PTGDR2ADRB3ALDH1A1MAPTCYP2C9 | |
| SCHEMBL4271773 | 0.86 | PTGDR2 (0.59) | PTGDR2ADRB3ALDH1A1MAPTCYP2C9 | |
| SCHEMBL4271611 | 0.81 | PTGDR2 (0.44) | PTGDR2ADRB3ALDH1A1MAPTCYP1A2 | |
| SCHEMBL4267944 | 0.80 | PTGDR2 (0.43) | PTGDR2ADRB3ALDH1A1MAPTCYP1A2 | |
| SCHEMBL4268388 | 0.79 | PTGDR2 (0.42) | PTGDR2ADRB3ALDH1A1CYP1A2GAA | |
| SCHEMBL4274214 | 0.79 | PTGDR2 (0.43) | PTGDR2ADRB3ALDH1A1MAPTCYP1A2 | |
| SCHEMBL4276034 | 0.79 | PTGDR2 (0.44) | PTGDR2ADRB3CYP1A2GAACYP2C9 | |
| SCHEMBL3168477 | 0.75 | PTGDR2 (0.73) | PTGDR2ADRB3CYP1A2GAACYP2C9 | |
| SCHEMBL3159417 | 0.73 | PTGDR2 (0.55) | PTGDR2CYP1A2GAACYP2C9PKM | |
| SCHEMBL4271751 | 0.72 | PTGDR2 (0.45) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |