Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 5/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4276046 | 0.84 | PTGDR2 (0.41) | PTGDR2PDK2 | |
| SCHEMBL4267501 | 0.84 | PTGDR2 (0.55) | PTGDR2PPARGADRB3ALDH1A1 | |
| SCHEMBL4271717 | 0.81 | PTGDR2 (0.41) | PTGDR2PPARGADRB3CYP1A2GAA | |
| SCHEMBL4267944 | 0.80 | PTGDR2 (0.43) | PTGDR2PPARGADRB3CYP1A2GAA | |
| SCHEMBL4268388 | 0.79 | PTGDR2 (0.42) | PTGDR2PPARGADRB3CYP1A2GAA | |
| SCHEMBL4272568 | 0.79 | PTGDR2 (0.41) | PTGDR2PPARGADRB3CYP1A2GAA | |
| SCHEMBL4283671 | 0.78 | FFAR4 (0.38) | PTGDR2PPARG | |
| SCHEMBL3165634 | 0.76 | PTGDR2 (0.54) | PTGDR2PPARGADRB3CYP1A2GAA | |
| SCHEMBL3164822 | 0.74 | PTGDR2 (0.72) | PTGDR2PPARGADRB3CYP1A2GAA | |
| SCHEMBL4271597 | 0.73 | TDP1 (0.48) | PPARGCYP1A2GAACYP2C9PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |