SCHEMBL4268015

SCHEMBL4268015

C=CC[Si](CC=C)(OCC)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.34
SMN1; SMN2 Q16637 4/20 0.33
HPGD P15428 3/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TP53 P04637 1/20 0.33
MMP9 P14780 1/20 0.33
MAPT P10636 1/20 0.32
GSTO1 P78417 1/20 0.32
TARBP2 Q15633 1/20 0.31
AKT1 P31749 1/20 0.31
AKT2 P31751 1/20 0.31
CHRNB2 P17787 1/20 0.30
CHRNB4 P30926 1/20 0.30
CHRNA3 P32297 1/20 0.30
CHRNA7 P36544 1/20 0.30
CHRNA4 P43681 1/20 0.30
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15302545 0.90 MEN1 (0.32) L3MBTL1
SCHEMBL1308621 0.84 ALDH1A1 (0.34) L3MBTL1KDM4EALDH1A1MAPTTAAR1
SCHEMBL4272275 0.84 ALDH1A1 (0.41) L3MBTL1SMN1; SMN2HPGDNPC1RAB9A
SCHEMBL12112058 0.84 MAPT (0.33) MAPT
SCHEMBL14956699 0.83 MEN1 (0.30)
SCHEMBL12112054 0.83 HSD17B10 (0.38) L3MBTL1SMN1; SMN2HPGDNPC1RAB9A
SCHEMBL1305375 0.80 ALDH1A1 (0.38) ALDH1A1CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL1308149 0.80 ESR1 (0.41) SMN1; SMN2ALDH1A1TP53MAPTOPRD1
SCHEMBL1306585 0.80 NR1H2 (0.31)
SCHEMBL1305649 0.80 RELA (0.36) SMN1; SMN2HPGDNPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7608673-B2 Organosilane compound and organosilica obtain therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2009-10-27 US disclosed
US-7608673-B2 Organosilane compound and organosilica obtain therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2009-10-27 US disclosed
US-20080227941-A1 Organosilane compound and organosilica obtained therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2008-09-18 US disclosed
US-20080227941-A1 Organosilane compound and organosilica obtained therefrom KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2008-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227941-A1 Organosilane compound and organosilica obtained therefrom OR51E2, WEE1, WEE2 L3MBTL1 864/4885SMN1; SMN2 4683/4885HPGD 3720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.