Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4268359 | 0.89 | KCNH2 (0.52) | KCNH2MTNR1AMTNR1BSIGMAR1HDAC3 | |
| SCHEMBL3172754 | 0.83 | KCNH2 (0.52) | KCNH2SIGMAR1HDAC3HDAC4HDAC1 | |
| SCHEMBL4268708 | 0.82 | KCNH2 (0.56) | KCNH2MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL4275377 | 0.81 | MTNR1A (0.35) | MTNR1AMTNR1BCYP4F2CYP4A11MEN1 | |
| SCHEMBL4275384 | 0.80 | PTGDR2 (0.55) | MEN1KMT2A | |
| SCHEMBL4266924 | 0.76 | CYP4A11 (0.52) | MTNR1AMTNR1BCYP4F2CYP4A11 | |
| SCHEMBL4268711 | 0.75 | KCNH2 (0.59) | KCNH2MTNR1AMTNR1BSIGMAR1 | |
| SCHEMBL4275709 | 0.75 | CYP4F2 (0.48) | MTNR1AMTNR1BCYP4F2CYP4A11 | |
| SCHEMBL16501807 | 0.70 | KCNH2 (0.67) | KCNH2SIGMAR1HDAC3HDAC4HDAC1 | |
| SCHEMBL4275379 | 0.69 | PTGDR2 (0.56) | CYP4F2CYP4A11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |