Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.52 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 5/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4268393 | 0.95 | CYP4F2 (0.56) | CYP3A4LMNACYP4F2CYP4A11MTNR1A | |
| SCHEMBL7608883 | 0.94 | CYP4F2 (0.55) | CYP3A4LMNACYP4F2CYP4A11MTNR1A | |
| SCHEMBL1561685 | 0.90 | CYP3A4 (0.56) | CYP3A4LMNACYP4F2CYP4A11MTNR1A | |
| SCHEMBL1790266 | 0.87 | PPARA (0.57) | CYP3A4LMNAMTNR1AMTNR1BACHE | |
| SCHEMBL27865972 | 0.86 | PPARA (0.63) | CYP3A4LMNAMTNR1AMTNR1BPPARG | |
| SCHEMBL4282046 | 0.86 | CYP3A4 (0.51) | CYP3A4LMNAMTNR1AMTNR1BACHE | |
| SCHEMBL30631323 | 0.86 | PPARA (0.63) | CYP3A4LMNAMTNR1AMTNR1BPPARG | |
| SCHEMBL4268400 | 0.84 | CYP4F2 (0.50) | CYP4F2CYP4A11MTNR1AMTNR1BACHE | |
| SCHEMBL5280181 | 0.84 | CYP3A4 (0.50) | CYP3A4LMNACYP4F2CYP4A11MTNR1A | |
| SCHEMBL1517301 | 0.84 | PPARA (0.66) | PPARGPPARAHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-B1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC (JP) | 2012-04-11 | — | — | EP | disclosed |
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |