Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2973364 | 0.99 | HPGDS (0.51) | HPGDSNPC1RAB9AALDH1A1GAA | |
| SCHEMBL4257174 | 0.83 | RAB9A (0.60) | HPGDSNPC1RAB9AALDH1A1GAA | |
| SCHEMBL4270395 | 0.82 | HPGDS (0.52) | HPGDSNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| Bromide SCHEMBL2972856 | 0.82 | NPC1 (0.62) | HPGDSNPC1RAB9AALDH1A1GAA | |
| Bromide SCHEMBL2973044 | 0.81 | HPGDS (0.51) | HPGDSNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3772350 | 0.81 | HPGDS (0.59) | HPGDSNPC1RAB9AALDH1A1GAA | |
| SCHEMBL2969067 | 0.81 | NPC1 (0.45) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL2980022 | 0.80 | SMN1; SMN2 (0.43) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL4259512 | 0.79 | HPGDS (0.59) | HPGDSNPC1RAB9AALDH1A1GAA | |
| SCHEMBL4262100 | 0.79 | HPGDS (0.59) | HPGDSNPC1RAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945635-B1 | THIAZOLYL PIPERIDINE DERIVATIVES USEFUL AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-05-06 | — | — | EP | disclosed |