SCHEMBL4268581

SCHEMBL4268581

CC=CCc1cccc(OCc2ccccc2)c1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.58
BCHE P06276 8/20 0.55
CYP4F2 P78329 1/20 0.55
CYP4A11 Q02928 1/20 0.55
MAOA P21397 1/20 0.54
LCK P06239 1/20 0.51
FFAR1 O14842 1/20 0.50
NR4A2 P43354 1/20 0.50
CCNB2 O95067 1/20 0.49
CDK1 P06493 1/20 0.49
CDK4 P11802 1/20 0.49
CCNB1 P14635 1/20 0.49
CCND1 P24385 1/20 0.49
CCNB3 Q8WWL7 1/20 0.49
ALOX5 P09917 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14382193 1.00 MAOB (0.58) MAOBBCHECYP4F2CYP4A11MAOA
SCHEMBL4268579 1.00 MAOB (0.58) MAOBBCHECYP4F2CYP4A11MAOA
SCHEMBL7489763 0.87 MAOB (0.62) MAOBBCHECYP4F2CYP4A11MAOA
SCHEMBL9130824 0.83 ALDH1A1 (0.48) MAOBFFAR1ALOX5
SCHEMBL28886740 0.83 TP53 (0.53) BCHE
SCHEMBL3178933 0.83 CYP4F2 (0.62) MAOBBCHECYP4F2CYP4A11MAOA
SCHEMBL3178924 0.83 CYP4F2 (0.62) MAOBBCHECYP4F2CYP4A11MAOA
SCHEMBL13859154 0.81 MAOB (0.64) MAOBBCHECYP4F2CYP4A11MAOA
SCHEMBL1009475 0.81 MAOB (0.68) MAOBBCHECYP4F2CYP4A11MAOA
SCHEMBL28969164 0.81 MAOB (0.58) MAOBBCHECYP4F2CYP4A11MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2094662-A1 POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS Astellas Pharma Inc. (JP) 2009-09-02 EP disclosed
WO-2008072784-A1 POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS ASTELLAS PHARMA INC. (JP) 2008-06-19 WO disclosed