Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4105943 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5266682 | 0.76 | LMNA (0.47) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4877258 | 0.74 | OPRK1 (0.59) | KDM4EHSD17B10USP2HPGDNPSR1 | |
| SCHEMBL4880160 | 0.74 | OPRK1 (0.53) | KDM4EHSD17B10USP2HPGDNPSR1 | |
| SCHEMBL7362801 | 0.73 | POLB (0.60) | KDM4EALDH1A1LMNAHSD17B10USP2 | |
| SCHEMBL3933293 | 0.72 | P2RY12 (0.62) | — | |
| SCHEMBL4115190 | 0.72 | P2RY12 (0.70) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3328130 | 0.71 | MEN1 (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4738835 | 0.70 | P2RY12 (0.58) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5844330 | 0.70 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227555-A2 | Novel Pyridine Compounds | ASTRAZENECA AB (SE) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227555-A2 | Novel Pyridine Compounds | P2RY12, P2RY1, P2RY11 | KDM4E 2316/4885ALDH1A1 1638/4885MEN1 2007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.