Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4273911 | 0.92 | RAB9A (0.43) | RAB9ANPC1CSF1RMAPK14FLT3 | |
| SCHEMBL4271546 | 0.85 | BRAF (0.32) | MAPK14RAF1BRAF | |
| SCHEMBL4281251 | 0.84 | BRAF (0.33) | RAF1BRAF | |
| SCHEMBL1521888 | 0.82 | RAB9A (0.45) | RAB9ANPC1CSF1RMAPK14FLT3 | |
| SCHEMBL4562970 | 0.81 | BRAF (0.42) | CSF1RMAPK14FLT3RETRAF1 | |
| SCHEMBL4563507 | 0.81 | KRAS (0.30) | RAF1BRAF | |
| SCHEMBL4271182 | 0.80 | BRAF (0.43) | CSF1RMAPK14FLT3RETRAF1 | |
| SCHEMBL1521923 | 0.80 | RAB9A (0.43) | RAB9ANPC1CSF1RMAPK14FLT3 | |
| SCHEMBL1521633 | 0.80 | RAB9A (0.43) | RAB9ANPC1CSF1RMAPK14FLT3 | |
| SCHEMBL1521517 | 0.79 | ABL1 (0.44) | RAB9ANPC1MAPK14RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | claimed |
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | disclosed |